Dennis J Slamon Selected Research

Enzymes

3/2011	Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.
1/2003	Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer.

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Dennis J Slamon Research Topics

Disease

85	Breast Neoplasms (Breast Cancer) 01/2024 - 02/2002
75	Neoplasms (Cancer) 12/2023 - 03/2002
15	Ovarian Neoplasms (Ovarian Cancer) 01/2023 - 01/2003
8	Neutropenia 03/2023 - 04/2002
7	Disease Progression 01/2020 - 03/2004
7	Neoplasm Metastasis (Metastasis) 01/2018 - 03/2002
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 07/2010
5	Retinoblastoma (Glioblastoma, Retinal) 10/2022 - 03/2002
3	Cardiotoxicity 01/2023 - 01/2014
3	Fatigue 11/2016 - 07/2002
3	Stomach Neoplasms (Stomach Cancer) 08/2015 - 03/2010
3	Lung Neoplasms (Lung Cancer) 12/2010 - 06/2002
2	Heart Diseases (Heart Disease) 01/2023 - 02/2002
2	Endometrial Neoplasms (Endometrial Cancer) 01/2023 - 05/2013
2	Ovarian Epithelial Carcinoma 01/2021 - 06/2008
2	Leukopenia 01/2018 - 11/2016
2	Melanoma (Melanoma, Malignant) 08/2015 - 08/2010
2	Renal Cell Carcinoma (Grawitz Tumor) 08/2013 - 01/2012
2	Exanthema (Rash) 02/2009 - 02/2007
2	Diarrhea 02/2009 - 02/2007
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2023
1	Mucositis 03/2023
1	Alopecia (Baldness) 03/2023
1	Heart Failure 01/2023
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2023

Drug/Important Bio-Agent (IBA)

34	Trastuzumab (Herceptin)FDA Link 11/2023 - 02/2002
22	Proteins (Proteins, Gene)FDA Link 12/2023 - 06/2002
17	palbociclibIBA 01/2024 - 01/2009
17	Hormones (Hormone)IBA 01/2023 - 01/2003
15	ErbB Receptors (EGF Receptor)IBA 01/2024 - 12/2003
12	Estrogen ReceptorsIBA 01/2024 - 01/2009
9	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 01/2005
9	Fulvestrant (Faslodex)FDA Link 01/2022 - 03/2013
9	Lapatinib (GW572016)FDA Link 01/2021 - 02/2006
8	Phosphotransferases (Kinase)IBA 01/2019 - 01/2003
7	Letrozole (Femara)FDA LinkGeneric 01/2024 - 01/2015
7	human ERBB2 proteinIBA 01/2023 - 04/2006
7	AnthracyclinesIBA 01/2023 - 05/2007
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2008
7	Cyclin-Dependent Kinase 4IBA 01/2021 - 08/2013
7	Phenobarbital (Luminal)FDA Link 11/2020 - 01/2005
7	Docetaxel (Taxotere)FDA Link 01/2014 - 05/2004
5	Monoclonal AntibodiesIBA 12/2023 - 01/2003
5	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2022 - 08/2013
5	Messenger RNA (mRNA)IBA 01/2021 - 02/2008
5	RNA (Ribonucleic Acid)IBA 02/2015 - 06/2008
5	PlatinumIBA 06/2014 - 05/2004
4	ribociclibIBA 01/2023 - 01/2018
4	InterferonsIBA 01/2017 - 02/2014
4	Bevacizumab (Avastin)FDA Link 06/2015 - 08/2010
4	Paclitaxel (Taxol)FDA LinkGeneric 06/2015 - 08/2004
4	Carboplatin (JM8)FDA LinkGeneric 06/2014 - 05/2004
3	Immunoconjugates (Immunoconjugate)IBA 12/2023 - 01/2019
3	abemaciclibIBA 10/2022 - 01/2018
3	taxaneIBA 10/2021 - 08/2004
3	Peptides (Polypeptides)IBA 01/2020 - 09/2005
3	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2020 - 03/2013
3	SteroidsIBA 01/2020 - 01/2003
3	5- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA 01/2019 - 04/2013
3	Epidermal Growth Factor (EGF)IBA 01/2018 - 12/2004
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2018 - 02/2009
3	MethyltransferasesIBA 08/2015 - 02/2010
3	Cisplatin (Platino)FDA LinkGeneric 06/2014 - 05/2004
2	talazoparibIBA 01/2023 - 01/2017
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2023 - 04/2006
2	AntigensIBA 01/2023 - 02/2014
2	Estrogens (Estrogen)FDA Link 10/2022 - 02/2016
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 06/2011
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2019 - 06/2013
2	2- (3- (4- ((2,6- dimethylmorpholino)methyl)styryl)- 1H- indazol- 6- yl)- 5'- methoxyspiro(cyclopropane- 1,3'- indolin)- 2'- oneIBA 01/2019 - 01/2019
2	Everolimus FDA Link 01/2018 - 02/2015
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018 - 07/2010
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017 - 08/2015
2	UbiquitinIBA 01/2017 - 08/2015
2	CyclinsIBA 02/2016 - 03/2002
2	Tamoxifen FDA LinkGeneric 02/2015 - 04/2006
2	Cyclin D1IBA 01/2015 - 03/2002
2	Transcription Factors (Transcription Factor)IBA 06/2014 - 04/2010
2	Tyrosine Kinase InhibitorsIBA 06/2013 - 02/2007
2	Dasatinib (BMS 354825)FDA Link 05/2013 - 11/2007
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2012 - 03/2004
2	PeriostinIBA 08/2011 - 11/2010
2	EnzymesIBA 03/2011 - 01/2003
2	hydrogen sulfite (bisulfite)IBA 02/2010 - 08/2005
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 04/2006 - 08/2004
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2005 - 01/2003
2	Complementary DNA (cDNA)IBA 01/2003 - 06/2002
1	Tumor Biomarkers (Tumor Markers)IBA 11/2023
1	claudin 6IBA 01/2023
1	Temozolomide (Temodar)FDA LinkGeneric 01/2023
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2023
1	Insulin-Like Growth Factor Binding Protein 3IBA 01/2023
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2023
1	MitogensIBA 10/2022
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 10/2022
1	tucatinibIBA 01/2022

Therapy/Procedure

50	Therapeutics 01/2023 - 01/2003
21	Drug Therapy (Chemotherapy) 03/2023 - 07/2002
5	Adjuvant Chemotherapy 06/2019 - 03/2006
2	Immunotherapy 01/2021 - 01/2015